Abstract: Based on the personal experience of front-line instrument manager and the characteristics of precision instruments, a new efficient management mode of precision and valuable instruments has been proposed. Taking precision and valuable instruments as the basis or target, the comprehensive opening of precision and valuable instruments and full playing to its due value with minimizing the cost of maintenance and operation can be realized. The quality of instrument management should be regarded as the most important guidance to evaluate the instrument manager, by which the subjective initiative of the instruments manager can be improved significantly. The ultimate goal is to make contributions to rejuvenating the country through science and education and building an innovative country.