Abstract: There are a large number of high-precision instruments and equipments, and interdisciplinary talents in the instrumental analysis center of universities and research institutes. Therefore, vigorously promoting the construction of quality management system not only can strengthen the support for basic research, but also play an important role in improving product quality, optimizing and upgrading industries, and promoting high-quality economic and social development. The importance of quality management system construction is analyzed from several aspects of open sharing of instruments, basic support, and guiding industrial transformation and upgrading. From the aspects of attaching importance to leadership, attaching equal importance to quality and technical supervisors, strengthening external training, cultivating employees' sense of ownership and enthusiasm, and attaching importance to internal audit and management review, the important measures for the construction of the quality management system are expounded.