CAI Zhi-wei, LIANG Jian-mou, CHEN Chao. Application of Scanning Electron Microscopy-Energy Dispersive Spectroscopy in Identification of Pharmaceutical Packaging Materials[J]. Analysis and Testing Technology and Instruments, 2022, 28(3): 260-266. DOI: 10.16495/j.1006-3757.2022.03.005
Citation: CAI Zhi-wei, LIANG Jian-mou, CHEN Chao. Application of Scanning Electron Microscopy-Energy Dispersive Spectroscopy in Identification of Pharmaceutical Packaging Materials[J]. Analysis and Testing Technology and Instruments, 2022, 28(3): 260-266. DOI: 10.16495/j.1006-3757.2022.03.005

Application of Scanning Electron Microscopy-Energy Dispersive Spectroscopy in Identification of Pharmaceutical Packaging Materials

  • A new identification method for pharmaceutical packaging materials has been developed based on the scanning electron microscope-energy dispersive spectroscope (SEM-EDS). SEM-EDS combined with infrared spectrophotometer and differential scanning calorimeter to analyze and identify the rubber stopper and laminated film of unknown composition, and the thickness was measured. The rubber stopper was a brominated butyl rubber stopper covered by ethylene-tetra-fluoro-ethylene with a thickness of about 24 μm, and the laminated film was a polyethylene terephthalate/low density polyethylene/aluminum/low density polyethylene laminated film with a thickness of about 38, 19, 13 and 14 μm, respectively. The SEM-EDS identification method for pharmaceutical packaging materials can determine the elemental composition and proportion of unknown compounds, thus solves the bottleneck encountered by the traditional identification, improves the efficiency and accuracy of identification greatly, and provides new ways for identifying pharmaceutical packaging materials.
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