Abstract: A method for the determination of 11 common pesticides in fruits, such as pesticides, fungicides and herbicides, was set up using the ultra-high performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS). The fruit samples were extracted with acetonitrile, and the extracts were purified using a filtered extraction column (m-PFC), monitored by the positive ion multiple reaction mode (MRM), and quantified by the external standard method. The detection limits of 11 pesticides in fruits were 1~3 μg/kg, with good linearity in the range of 1.0~100.0 ng/mL, with the correlation coefficient r not less than 0.996 9. The standards of 5, 20 and 50 μg/kg were added to the sample matrix for spiked recovery tests. The average recoveries rate of 11 pesticides were 88.9%~110.1%, and the relative standard deviation (RSD) were 2.7%~8.5% (n=6). The method is simple and sensitive, and can accurately determine 11 pesticide residues in fruits.