Abstract: With the continuous development of science and technology, strengthening the management of large instrument archives will contribute to the stable operation of shared platform instruments and the smooth conduct of experiments. In order to trace back to the source, the problems existing in the management of large instrument archives on the sharing platform in colleges and universities has been studied. Based on the public technology platform website of School of Medicine of Zhejiang University, the instrument information management mode was explored and innovated. The office automation (OA) platform was established for the whole cycle of instrument application, research, demonstration, bidding, procurement, acceptance, operation and maintenance, scrapping and so on. The established OA platform can realize the convenient, scientific and intelligent instrument file management mode, with a view to provide a reference for the effective management of instrument archives on the sharing platform of colleges and universities and realize resource sharing.