Abstract: Non-steroidal anti-inflammatory drugs(NSAIDs) are widely used in the treatment of human diseases because of their good anti-inflammatory, antipyretic and analgesic effects. These non-steroidal drugs that entered the human body cannot completely be metabolized by the liver during the treatment of inflammation and the rest of its metabolites excreted through the excretory system of body. Large amounts of data indicate that the residual drugs in the environment are directly or indirectly presented as food safety problems, therefore it becomes one of the main investigations in many fields, such as analytical chemistry and material chemistry. Sample pretreatment techniques are frequently used to carry out the adsorption and separation analysis due to the complexity of the sample matrix, the wide range of analytical components and the low content of the target analyte. In recent years the problems caused by non-steroidal anti-inflammatory drugs and the variety of analysis of the separation and detection techniques of the non-steroidal anti-inflammatory drugs mechanism for the environment are summarized. The core of separation and determination is the selection of extracting materials. The research progress on non steroidal anti-inflammatory drugs for the effective, outstanding adsorption and separation of materials are reviewed.