Abstract: Hyperglycemia, hypertension and hyperlipemia, collectively known as the "three-hypers", have already become the common diseases that threaten people's health. Chinese patent medicines and health food are more and more frequently used in the daily prevention and treatment of these diseases. However, some chemical substances have been illegally added for profit, causing safety hazards to patients. The types of illegally added chemical medicines in Chinese patent medicines and health foods that regulate "three-hypers" in recent years were summarized, and the research situation of the national standard supplementary testing methods and other analysis methods for these of illegally added medicines were introduced. Finally, according to the current situation of illegal addition, further research directions are analyzed in order to provide reference for the detection on illegal addition.