Abstract: A method was developed to determine the residues of 2-chloroethanol in gelatin hollow capsules using headspace gas chromatography-electron capture detector method. The physical properties of gelatin disappeared when the gelatin hollow capsule solution was salting out with NaCl solution. The content of 2-chloroethanol in gelatin hollow capsule solution was analyzed by headspace gas chromatography-electron capture detector method. The results showed that 2-chloroethanol had a good linear relationship in the range of 10~35 μg/g, with an r value of 0.999 4. The limits of quantitation and limits of detection were 10 and 5 μg/g, respectively. The recoveries ranged from 92.1%~102.2%, the relative standard deviation (RSD) were all less than 10%. The samples were tested by the method. The method is simple, accurate and sensitive and effective in solving the matrix effect of gelatin hollow capsules, and can be used for the quantitative analysis of 2-chloroethanol in commercially available gelatin hollow capsules.