Abstract: Using the welding pool of sampling, an X-ray fluorescence determination method of Zr、Si、Fe、Ti、Al、Ca in the zirconium ore mine is established. The use of the state level standard material mixed with zirconium dioxide to make a blead standard material solve the insufficiency of the standard of zirconium ore. Sample:partial boric acid lithium mixed flux=1: 20 melted into a glass prototype, using the experience coefficient method and internal standard method of scattering line to correct the overlapping effect of the spectral lines of elements and matrix effect, the standard material and mixed standard samples were analyzed, and the resuits of the standard material agreed with the recommended value. The relative standard deviations (RSD %) were less than 3.6%. This method can meet the determination of the major and minor content elements in the high conteat zirconium ore.